Which medication is used to reduce cravings and prevent relapse in alcohol dependence and is started during withdrawal?

Naltrexone

Disulfiram

Methadone

Acamprosate

Medications to support abstinence in alcohol use disorder work by reducing cravings and preventing relapse, especially in the early recovery period after withdrawal. Acamprosate helps stabilize brain signaling that becomes imbalanced after stopping alcohol, particularly by modulating glutamate activity. This dampens withdrawal-related cravings and the urge to drink, making it easier to maintain abstinence as the brain readjusts. It’s typically started once withdrawal is underway and continued during early recovery to support ongoing sobriety.

Other options function differently: one blocks alcohol’s rewarding effects by opioid receptors, which can help prevent relapse but is generally used after detox; another creates an unpleasant reaction if alcohol is consumed, acting as a deterrent and also started after detox; and the last is an opioid agonist used for opioid dependence, not alcohol.

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