Management of Type IV hypersensitivity typically includes:

• A. Allergen avoidance
• B. Steroids
• C. Interferon, cyclophosphamide
• D. Cyclosporine

Answer: (A)

Type IV hypersensitivity is driven by T cells recognizing a specific antigen and causing inflammation when exposed. The most effective management is to identify and avoid the offending allergen, so the immune system has nothing to react to. This preventive approach reduces future sensitization and flare-ups. In practice, this is supported by strategies like patch testing to pinpoint the culprit and avoiding contact with it. While steroids can help tame symptoms during a flare, they don’t address the underlying cause. Systemic immunosuppressants like interferon, cyclophosphamide, or cyclosporine are not usual first-line treatments for typical Type IV reactions and carry more risks. Thus allergen avoidance is the key management step.