What is the normal range for serum chloride?

• A. 80-90
• B. 96-106
• C. 110-120
• D. 120-130

Answer: (B)

Chloride is a major extracellular anion that helps preserve electrical neutrality and supports acid-base balance alongside sodium and bicarbonate. The body keeps serum chloride in a fairly tight range, about 96 to 106 mEq/L. Values below this range indicate hypochloremia, which can occur with loss of gastric HCl from vomiting or suction, diuretic use, or metabolic alkalosis, shifting the body toward a more alkaline state. Values above this range indicate hyperchloremia, which can accompany dehydration with high-chloride fluids like saline or certain forms of metabolic acidosis, among other conditions. Because 96–106 mEq/L best fits the normal physiologic regulation, that range is the correct reference.