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Multiple Choice

Which is a sign of hypercalcemia?

High calcium dampens neuromuscular excitability, so excess calcium tends to cause weakness and fatigue rather than increased nerve activity. This makes muscle weakness the most characteristic sign of hypercalcemia. Reflexes are often reduced, not heightened, because the muscles respond less vigorously when calcium is elevated. The other signs are less typical: hyperreflexia suggests increased nerve irritability, which isn’t how hypercalcemia usually presents. Seizures can occur only in very severe cases or due to other factors, not as a common early sign. Tachycardia can happen in some conditions, but the classic and most consistent sign tied to elevated calcium is proximal muscle weakness.

High calcium dampens neuromuscular excitability, so excess calcium tends to cause weakness and fatigue rather than increased nerve activity. This makes muscle weakness the most characteristic sign of hypercalcemia. Reflexes are often reduced, not heightened, because the muscles respond less vigorously when calcium is elevated.

The other signs are less typical: hyperreflexia suggests increased nerve irritability, which isn’t how hypercalcemia usually presents. Seizures can occur only in very severe cases or due to other factors, not as a common early sign. Tachycardia can happen in some conditions, but the classic and most consistent sign tied to elevated calcium is proximal muscle weakness.